TIMP4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TIMP4.
Immunogen
A synthetic peptide corresponding to amino acids at C-terminus of human TIMP4.
Host
Rabbit
Theoretical MW (kDa)
25.5
Reactivity
Human, Mouse, Rat
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot analysis of rat kidney tissue lysate. Using TIMP4 polyclonal antibody (Cat # PAB8015) . -
Gene Info — TIMP4
Entrez GeneID
7079Gene Name
TIMP4
Gene Alias
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Gene Description
TIMP metallopeptidase inhibitor 4
Omim ID
601915Gene Ontology
HyperlinkGene Summary
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq
Other Designations
tissue inhibitor of metalloproteinase 4
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Interactome
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Disease
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Publication Reference
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Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively.
Olson TM, Hirohata S, Ye J, Leco K, Seldin MF, Apte SS.
Genomics 1998 Jul; 51(1):148.
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Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2.
Bigg HF, Shi YE, Liu YE, Steffensen B, Overall CM.
The Journal of Biological Chemistry 1997 Jun; 272(24):15496.
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Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively.
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