GRIN2B polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRIN2B.
Immunogen
A synthetic peptide corresponding to amino acids at N-terminus of human GRIN2B.
Host
Rabbit
Theoretical MW (kDa)
166
Reactivity
Human, Mouse, Rabbit, Rat
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL)
Immunohistochemistry (Frozen sections) (0.5-1 ug/mL)
Immunocytochemistry (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage Instruction
Store at -20°C. After reconstitution with deionized water, store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and Thimerosol: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of rat brain tissue lysate. Using GRIN2B polyclonal antibody (Cat # PAB7997) .Immunofluorescence
Immunofluorescence analysis of paraffin-embedded rat brain sections, stain GRIN2B in cytoplasm DAB chromogenic reaction. -
Gene Info — GRIN2B
Entrez GeneID
2904Gene Name
GRIN2B
Gene Alias
MGC142178, MGC142180, NMDAR2B, NR2B, hNR3
Gene Description
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Omim ID
138252Gene Ontology
HyperlinkGene Summary
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq
Other Designations
N-methyl-D-aspartate receptor subunit 2B|glutamate receptor subunit epsilon-2
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Interactome
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Pathway
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Publication Reference
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Genetic enhancement of learning and memory in mice.
Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, Liu G, Tsien JZ.
Nature 1999 Sep; 401(6748):63.
Application:WB-Ti, Mouse, Cortex, Hippocampus.
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Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12.
Mandich P, Schito AM, Bellone E, Antonacci R, Finelli P, Rocchi M, Ajmar F.
Genomics 1994 Jul; 22(1):216.
Application:IF, IHC, WB-Ce, WB-Tr, Human, Mouse, Brains, Human Peripheral Blood, NIH/3T3 cells.
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Genetic enhancement of learning and memory in mice.
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