NGF polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NGF.
Immunogen
A synthetic peptide corresponding to amino acids at C-terminus of human NGF.
Host
Rabbit
Theoretical MW (kDa)
26.9
Reactivity
Human, Mouse, Rat
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of rat brain tissue lysate. Using NGF polyclonal antibody (Cat # PAB7994) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded rat brain sections, stain NGF in cytoplasm DAB chromogenic reaction. -
Gene Info — NGF
Entrez GeneID
4803Gene Name
NGF
Gene Alias
Beta-NGF, HSAN5, MGC161426, MGC161428, NGFB
Gene Description
nerve growth factor (beta polypeptide)
Gene Ontology
HyperlinkGene Summary
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq
Other Designations
OTTHUMP00000013653|beta-nerve growth factor|nerve growth factor, beta polypeptide|nerve growth factor, beta subunit
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Interactome
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Pathway
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Disease
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Publication Reference
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A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception.
Einarsdottir E, Carlsson A, Minde J, Toolanen G, Svensson O, Solders G, Holmgren G, Holmberg D, Holmberg M.
Human Molecular Genetics 2004 Feb; 13(8):799.
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Two thyroid hormone regulated genes, the beta-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes.
Dracopoli NC, Rose E, Whitfield GK, Guidon PT Jr, Bale SJ, Chance PA, Kourides IA, Housman DE.
Genomics 1988 Aug; 3(2):161.
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The human gene for the beta subunit of nerve growth factor is located on the proximal short arm of chromosome 1.
Francke U, de Martinville B, Coussens L, Ullrich A.
Science 1983 Dec; 222(4629):1248.
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A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception.
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