MPO polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MPO.
Immunogen
A synthetic peptide corresponding to amino acids at C-terminus of human MPO.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5~1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of rat brain tissue lysate. Using MPO polyclonal antibody (Cat # PAB7992) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human ovary sections using MPO polyclonal antibody (Cat # PAB7992) . -
Gene Info — MPO
Entrez GeneID
4353Gene Name
MPO
Gene Alias
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Gene Description
myeloperoxidase
Gene Ontology
HyperlinkGene Summary
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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Hydroxytyrosol ameliorates metabolic, cardiovascular and liver changes in a rat model of diet-induced metabolic syndrome: pharmacological and metabolism-based investigation.
Poudyal H, Lemonakis N, Efentakis P, Gikas E, Halabalaki M, Andreadou I, Skaltsounis L, Brown L.
Pharmacological Research 2016 Dec; 117:32.
Application:IHC, Rat, Rat liver and heart.
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Activated human valvular interstitial cells sustain IL-17 production to recruit neutrophils in infective endocarditis.
Yeh CY, Shun CT, Kuo YM, Jung CJ, Hsieh SC, Chiu YL, Chen JW, Hsu RB, Yang CJ, Chia JS.
Infection and Immunity 2015 Jun; 83(6):2202.
Application:ELISA, IHC, Human, Supernatants collected from PMNs or MNCs culture, Valvular interstitial cells.
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Smg1 haploinsufficiency predisposes to tumor formation and inflammation.
Roberts TL, Ho U, Luff J, Lee CS, Apte SH, Macdonald KP, Raggat LJ, Pettit AR, Morrow CA, Waters MJ, Chen P, Woods RG, Thomas GP, St Pierre L, Farah CS, Clarke RA, Brown JA, Lavin MF.
PNAS 2012 Dec; 110(4):E285.
Application:IHC, Mouse, Mouse lymphoma.
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Myeloperoxidase.
Klebanoff SJ.
Proceedings of the Association of American Physicians 1999 Sep; 111(5):383.
Application:IHC, WB, Human, Monocytes, Neutrophils.
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Myeloperoxidase: a myeloid cell nuclear antigen with DNA-binding properties.
Murao S, Stevens FJ, Ito A, Huberman E.
PNAS 1988 Feb; 85(4):1232.
Application:AFC, IEM, RIA, Human, HL-60 cells, Human spleen, KG-1 cells, ML-2 cells, Monocytes, Recombinant proteins, THP-1 cells.
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Biosynthesis and processing of myeloperoxidase--a marker for myeloid cell differentiation.
Nauseef WM, Olsson I, Arnljots K.
European Journal of Haematology 1988 Feb; 40(2):97.
Application:ICC, IP, WB-Ce, WB-Tr, Human, HL-60 cells, Myeloid cells, Neutrophils.
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Hydroxytyrosol ameliorates metabolic, cardiovascular and liver changes in a rat model of diet-induced metabolic syndrome: pharmacological and metabolism-based investigation.
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