GAP43 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of rat brain tissue lysate. Using GAP43 polyclonal antibody (Cat # PAB7977) .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded rat brain sections using GAP43 polyclonal antibody (Cat # PAB7977) .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GAP43.
Immunogen
A synthetic peptide corresponding to C-terminus of human GAP43.
Host
Rabbit
Theoretical MW (kDa)
24.8
Reactivity
Human, Mouse, Rat
Specificity
Identical to the related rat and mouse sequence.
Form
Lyophilized
Purification
Immunoaffinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of rat brain tissue lysate. Using GAP43 polyclonal antibody (Cat # PAB7977) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded rat brain sections using GAP43 polyclonal antibody (Cat # PAB7977) . -
Gene Info — GAP43
Entrez GeneID
2596Gene Name
GAP43
Gene Alias
B-50, PP46
Gene Description
growth associated protein 43
Omim ID
162060Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
axonal membrane protein GAP-43|calmodulin-binding protein P-57|nerve growth-related peptide GAP43|neural phosphoprotein B-50|neuromodulin|neuron growth-associated protein 43|protein F1
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Interactome
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Disease
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Publication Reference
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Regulation of GAP-43 expression by chronic desipramine treatment in rat cultured hippocampal cells.
Chen B, Wang JF, Sun X, Young LT.
Biological Psychiatry 2003 Mar; 53(6):530.
Application：WB-Ti, Rat, Cortex, Hippocampus.
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Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43.
Strittmatter SM, Fankhauser C, Huang PL, Mashimo H, Fishman MC.
Cell 1995 Feb; 80(3):445.
Application：IF, WB-Ti, Mouse, Mouse brains, Mouse embryonic stem cells.
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Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human.
Kosik KS, Orecchio LD, Bruns GA, Benowitz LI, MacDonald GP, Cox DR, Neve RL.
Neuron 1988 Apr; 1(2):127.
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Regulation of GAP-43 expression by chronic desipramine treatment in rat cultured hippocampal cells.
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