CXCR2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CXCR2.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human CXCR2.
Host
Rabbit
Theoretical MW (kDa)
40.7
Reactivity
Human, Rat
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of human colon cancer lysate. Using CXCR2 polyclonal antibody (Cat # PAB7969) . -
Gene Info — CXCR2
Entrez GeneID
3579Gene Name
CXCR2
Gene Alias
CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB
Gene Description
chemokine (C-X-C motif) receptor 2
Omim ID
146928Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq
Other Designations
C-X-C chemokine receptor type 2|CXC-R2|CXCR-2|CXCR2 gene for IL8 receptor type B|GRO/MGSA receptor|IL-8 receptor type 2|IL-8R B|chemokine (CXC) receptor 2|high affinity interleukin-8 receptor B|interleukin 8 receptor B|interleukin 8 receptor type 2|interl
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Interactome
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Pathway
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Disease
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Publication Reference
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Structure, genomic organization, and expression of the human interleukin-8 receptor B gene.
Sprenger H, Lloyd AR, Lautens LL, Bonner TI, Kelvin DJ.
The Journal of Biological Chemistry 1994 Apr; 269(15):11065.
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Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.
Cerretti DP, Kozlosky CJ, Vanden Bos T, Nelson N, Gearing DP, Beckmann MP.
Molecular Immunology 1993 Mar; 30(4):359.
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Cloning of complementary DNA encoding a functional human interleukin-8 receptor.
Murphy PM, Tiffany HL.
Science 1991 Sep; 253(5025):1280.
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Structure, genomic organization, and expression of the human interleukin-8 receptor B gene.
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