GJA1 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of rat cardiac muscle tissue lysate. Using GJA1 polyclonal antibody (Cat # PAB7966) .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded rectal carcinoma sections, stain GJA1 in cytoplasm DAB chromogenic reaction.
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GJA1.
Immunogen
A synthetic peptide corresponding to amino acids at C-terminus of human GJA1.
Host
Rabbit
Theoretical MW (kDa)
43
Reactivity
Human, Mouse, Rat
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
Western blot analysis of rat cardiac muscle tissue lysate. Using GJA1 polyclonal antibody (Cat # PAB7966) .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded rectal carcinoma sections, stain GJA1 in cytoplasm DAB chromogenic reaction. -
Gene Info — GJA1
Entrez GeneID
2697Gene Name
GJA1
Gene Alias
CX43, DFNB38, GJAL, ODDD
Gene Description
gap junction protein, alpha 1, 43kDa
Gene Ontology
HyperlinkGene Summary
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. [provided by RefSeq
Other Designations
OTTHUMP00000017111|connexin 43|gap junction 43 kDa heart protein|gap junction protein, alpha-like
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Comparison between renal denervation and metoprolol on the susceptibility of ventricular arrhythmias in rats with myocardial infarction.
Jiang W, Chen C, Huo J, Lu D, Jiang Z, Geng J, Xu H, Shan Q.
Scientific Reports 2018 Jul; 8(1):10206.
Application：WB-Ti, Rat, Heart.
-
Mutations in GJA1 (connexin 43) are associated with non-syndromic autosomal recessive deafness.
Liu XZ, Xia XJ, Adams J, Chen ZY, Welch KO, Tekin M, Ouyang XM, Kristiansen A, Pandya A, Balkany T, Arnos KS, Nance WE.
Human Molecular Genetics 2001 Dec; 10(25):2945.
Application：IHC-P, Mouse, Mouse cochlea.
-
Mutations of the Connexin43 gap-junction gene in patients with heart malformations and defects of laterality.
Britz-Cunningham SH, Shah MM, Zuppan CW, Fletcher WH.
The New England Journal of Medicine 1995 May; 332(20):1323.
Application：IF, WB-Tr, Mouse, L929 Cells.
-
Comparison between renal denervation and metoprolol on the susceptibility of ventricular arrhythmias in rats with myocardial infarction.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com