GJB2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against partial synthetic peptide of human GJB2.
Immunogen
A synthetic peptide corresponding to amino acids 1-16 of human GJB2.
Sequence
MDWGTLQTILGGVNKH
Host
Rabbit
Theoretical MW (kDa)
26
Reactivity
Human, Mouse, Rat
Form
Lyophilized
Purification
Immunogen affinity purification
Isotype
IgG
Recommend Usage
Western Blot (0.1-0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.2 mg Na2HPO4, 0.9 mg NaCl (0.05 mg Thimerosal, 0.05 mg sodium azide, 5 mg BSA).
Storage Instruction
Store at -20°C.
After reconstitution with 0.2 mL of distilled water and concentration will be 500 ug/mL, store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and Thimerosol: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of rat liver tissue lysate. Using GJB2 polyclonal antibody (Cat # PAB7965) . -
Gene Info — GJB2
Entrez GeneID
2706Protein Accession#
P29033Gene Name
GJB2
Gene Alias
CX26, DFNA3, DFNB1, HID, KID, NSRD1, PPK
Gene Description
gap junction protein, beta 2, 26kDa
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq
Other Designations
OTTHUMP00000018093|OTTHUMP00000018094|connexin 26|gap junction protein beta 2|gap junction protein, beta 2, 26kD (connexin 26)
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Interactome
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Disease
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Publication Reference
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Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response.
Djalilian AR, McGaughey D, Patel S, Seo EY, Yang C, Cheng J, Tomic M, Sinha S, Ishida-Yamamoto A, Segre JA.
The Journal of Clinical Investigation 2006 May; 116(5):1243.
Application:IF, IHC-Fr, IHC-P, Mouse, Mouse skin.
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Connexin 26 gene (GJB2) mutation modulates the severity of hearing loss associated with the 1555A-->G mitochondrial mutation.
Abe S, Kelley PM, Kimberling WJ, Usami SI.
American Journal of Medical Genetics 2001 Nov; 103(4):334.
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Assignment of connexin 26 (GJB2) and 46 (GJA3) genes to human chromosome 13q11-->q12 and mouse chromosome 14D1-E1 by in situ hybridization.
C Mignon, C Fromaget, M G Mattei, D Gros, H Yamasaki, M Mesnil.
Cytogenetics and Cell Genetics 1996 Jan; 72(2-3):185.
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Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response.
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