Western blot of human endothelial cells untreated (lane 1) or treated with pervanadate (1 mM) for 30 min (lanes 2, 3 & 4). The blots were probed with CDH2 (phospho Y820) polyclonal antibody (Cat # PAB7930). The latter antibody was used in the presence of no peptide (lane 2), phospho-CDH2 (Tyr-820) peptide (lane 3), or phospho-CDH2 (Tyr-860) peptide (lane 4).
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq