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Last updated: 2016/10/16
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DOK1 (phospho S450) polyclonal antibody

  • Catalog # : PAB7908
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of DOK1.
  • Immunogen:
  • Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S450 of human DOK1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • This sequence is conserved in Dok1 from rat (Ser-449) and mouse (Ser-451). The site is not conserved in other Dok family members.
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:2000)
    Western Blot (1:500)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot of Jurkat cells stimulated with calyculin A (100 nM, 30 min) (lane 1) followed by lambda phosphatase (lane 2) treatment. The blots were probed with DOK1 (phospho S450) polyclonal antibody (Cat # PAB7908).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 1796
  • Gene Name:
  • DOK1
  • Gene Alias:
  • MGC117395,MGC138860,P62DOK
  • Gene Description:
  • docking protein 1, 62kDa (downstream of tyrosine kinase 1)
  • Gene Summary:
  • Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. [provided by RefSeq
  • Other Designations:
  • Downstream of tyrosine kinase 1,docking protein 1,docking protein 1 (downstream of tyrosine kinase 1),docking protein 1, 62kD (downstream of tyrosine kinase 1)
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