PXN (phospho S178) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of PXN.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S178 of human PXN.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This human sequence is highly conserved in rat and mouse paxillin.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of A-431 cells (20 ug/lane) serum starved overnight. Then untreated (lane 1) or treated (lane 2) with EGF (100 ng/mL) for 5 min. The blot was probed with PXN (phospho S178) polyclonal antibody (Cat # PAB7904).Enzyme-linked Immunoabsorbent Assay
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Gene Info — PXN
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Interactome
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Pathway
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Disease
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Publication Reference
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A role for JNK-paxillin signaling in cell migration.
Huang C, Jacobson K, Schaller MD.
Cell Cycle 2004 Jan; 3(1):4.
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Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf-->MEK-->ERK pathway.
Woodrow MA, Woods D, Cherwinski HM, Stokoe D, McMahon M.
Experimental Cell Research 2003 Jul; 287(2):325.
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JNK phosphorylates paxillin and regulates cell migration.
Huang C, Rajfur Z, Borchers C, Schaller MD, Jacobson K.
Nature 2003 Jul; 424(6945):219.
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A role for JNK-paxillin signaling in cell migration.
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