Western blots of human PAK6 recombinant protein phosphorylated by ERK2. The blot was exposed to lambda phosphatase (lane 2) then probed with PAK6 (phospho S165) polyclonal antibody (Cat # PAB7902) (lanes 1-4). The PAK6 antibody was used in the presence of PAK6 (Ser-165) antibody was used in the presence of phospho-PAK6 (Ser-165) peptide (lane 3) or a non-specific phospho-serine peptide (lane 4).
This gene encodes a member of the p21-activated kinase (PAK) family. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. This gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
p21(CDKN1A)-activated kinase 6,p21-activated kinase 6,p21-activated protein kinase 6