Western blot of COS-7 cells untransfected (lane 1) or transfected with HA-tagged mouse neuropilin-1 (lane 2). Blots were probed with NRP1 polyclonal antibody (Cat # PAB7896).
Immunocytochemical double labeling using NRP1 polyclonal antibody (Cat # PAB7896) in COS-7 cells mock transfected (A) or transfected with NRP1 constructs (B). The specificity of the binding in (B) was demonstrated by using NRP1 peptide, in the presence of the NRP1 polyclonal antibody (Cat # PAB7896) (C).
NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM