PAK6 polyclonal antibody
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More Files
- More Functions
Western Blot (Recombinant protein)
Western blots of human PAK6 recombinant protein phosphorylated by ERK2. The blot was exposed to lambda phosphatase (lane 2) then probed with PAK6 polyclonal antibody (Cat # PAB7884). The PAK6 antibody was used in the presence of a non-specific peptide (lane 3) or PAK6 (N-terminal) peptide (lane 4).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PAK6.
Immunogen
A synthetic peptide corresponding to N-terminus of human PAK6.
Host
Rabbit
Reactivity
Human
Specificity
The sequence used has two amino acid differences compared to rat and mouse PAK6.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blots of human PAK6 recombinant protein phosphorylated by ERK2. The blot was exposed to lambda phosphatase (lane 2) then probed with PAK6 polyclonal antibody (Cat # PAB7884). The PAK6 antibody was used in the presence of a non-specific peptide (lane 3) or PAK6 (N-terminal) peptide (lane 4).Enzyme-linked Immunoabsorbent Assay
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Gene Info — PAK6
Entrez GeneID
56924Protein Accession#
Q9NQU5Gene Name
PAK6
Gene Alias
PAK5
Gene Description
p21 protein (Cdc42/Rac)-activated kinase 6
Omim ID
608110Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the p21-activated kinase (PAK) family. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. This gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
p21(CDKN1A)-activated kinase 6|p21-activated kinase 6|p21-activated protein kinase 6
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Interactome
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Pathway
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Disease
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Publication Reference
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Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase.
Kaur R, Liu X, Gjoerup O, Zhang A, Yuan X, Balk SP, Schneider MC, Lu ML.
The Journal of Biological Chemistry 2005 Feb; 280(5):3323.
Application：IP, WB-Tr, Human, HEK 293 cells.
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Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling.
Schrantz N, da Silva Correia J, Fowler B, Ge Q, Sun Z, Bokoch GM.
The Journal of Biological Chemistry 2004 Jan; 279(3):1922.
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AR and ER interaction with a p21-activated kinase (PAK6).
Lee SR, Ramos SM, Ko A, Masiello D, Swanson KD, Lu ML, Balk SP.
Molecular Endocrinology 2002 Jan; 16(1):85.
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Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase.
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