WASF1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot of human SYF cSrc-transformed cells. Blots were were probed with WASF1 polyclonal antibody (Cat # PAB7878) at a dilution of 1:1000 (lane 1), 1:2000 (lane 2) or 1:4000 (lane 3).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of WASF1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus half of human WASF1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This sequence has high homology with similar regions in rat and mouse WAVE1, and has less than 50% homology to similar regions in human WAVE2 and WAVE3.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot of human SYF cSrc-transformed cells. Blots were were probed with WASF1 polyclonal antibody (Cat # PAB7878) at a dilution of 1:1000 (lane 1), 1:2000 (lane 2) or 1:4000 (lane 3).Enzyme-linked Immunoabsorbent Assay
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Gene Info — WASF1
Entrez GeneID
8936Gene Name
WASF1
Gene Alias
FLJ31482, KIAA0269, SCAR1, WAVE, WAVE1
Gene Description
WAS protein family, member 1
Omim ID
605035Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000016990|Wiskott-Aldrich syndrome protein family member 1|homology of dictyostelium scar 1|verprolin homology domain-containing protein 1
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Interactome
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Pathway
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Publication Reference
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Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation.
Leng Y, Zhang J, Badour K, Arpaia E, Freeman S, Cheung P, Siu M, Siminovitch K.
PNAS 2005 Jan; 102(4):1098.
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Crystal growth of carbonate apatite using a CaCO3 flux.
Suetsugu Y, Tanaka J.
Journal of Materials Science. Materials in Medicine 1999 Sep; 10(9):561.
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Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation.
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