UCN3 polyclonal antibody
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More Files
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Western Blot (Transfected lysate)
HEK293 lysate (10 ug protein in RIPA buffer) over expressing human UCN3 with DYKDDDDK tag probed with UCN3 polyclonal antibody (Cat # PAB7613) (1 ug/mL) in Lane 1 and probed with anti- DYKDDDDK Tag (1/3000) in lane 3. Mock-transfected HEK293 probed with UCN3 polyclonal antibody (Cat # PAB7613) (1 mg/mL) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of UCN3.
Immunogen
A synthetic peptide corresponding to internal region of human UCN3.
Sequence
C-KPRQDTAKSPHRTK
Host
Goat
Theoretical MW (kDa)
18
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
HEK293 lysate (10 ug protein in RIPA buffer) over expressing human UCN3 with DYKDDDDK tag probed with UCN3 polyclonal antibody (Cat # PAB7613) (1 ug/mL) in Lane 1 and probed with anti- DYKDDDDK Tag (1/3000) in lane 3. Mock-transfected HEK293 probed with UCN3 polyclonal antibody (Cat # PAB7613) (1 mg/mL) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — UCN3
Entrez GeneID
114131Protein Accession#
NP_444277.2Gene Name
UCN3
Gene Alias
MGC119002, SCP, SPC, UCNIII
Gene Description
urocortin 3 (stresscopin)
Omim ID
605901Gene Ontology
HyperlinkGene Summary
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq
Other Designations
OTTHUMP00000018999|stresscopin|urocortin 3|urocortin III
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Interactome
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Pathway
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Disease
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Publication Reference
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Cross species association examination of UCN3 and CRHR2 as potential pharmacological targets for antiobesity drugs.
Jiang Z, Michal JJ, Williams GA, Daniels TF, Kunej T.
PLoS One 2006 Dec; 1:e80.
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Cross species association examination of UCN3 and CRHR2 as potential pharmacological targets for antiobesity drugs.
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