SENP6 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SENP6.
Immunogen
A synthetic peptide corresponding to human SENP6.
Sequence
C-KPKYEPNPHYHEN
Host
Goat
Theoretical MW (kDa)
125, 126
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_001093879.1; NP_056386.2).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
SENP6 polyclonal antibody (Cat # PAB7602) (0.5 ug/mL) staining of HeLa cell nuclear lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SENP6
Entrez GeneID
26054Protein Accession#
NP_001093879.1;NP_056386.2Gene Name
SENP6
Gene Alias
FLJ11355, FLJ11887, KIAA0389, KIAA0797, SSP1, SUSP1
Gene Description
SUMO1/sentrin specific peptidase 6
Omim ID
605003Gene Ontology
HyperlinkGene Summary
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM
Other Designations
2810017C20Rik|SUMO-1-specific protease|SUMO1/sentrin specific protease 6
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Interactome
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Publication Reference
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Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1.
Choi SJ, Chung SS, Rho EJ, Lee HW, Lee MH, Choi HS, Seol JH, Baek SH, Bang OS, Chung CH.
The Journal of Biological Chemistry 2006 Oct; 281(41):30669.
Application:IF, WB, Human, HEK 293T, HeLa cells.
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Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1.
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