PPP2R3A polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PPP2R3A.
Immunogen
A synthetic peptide corresponding to human PPP2R3A.
Sequence
C-QKDVENDGPEPSD
Host
Goat
Theoretical MW (kDa)
130, 61.1
Specificity
This antibody is expected to recognize both reported isoforms (NP_002709.2; NP_871626.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — PPP2R3A
Entrez GeneID
5523Protein Accession#
NP_002709.2;NP_871626.1Gene Name
PPP2R3A
Gene Alias
PPP2R3, PR130, PR72
Gene Description
protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha
Omim ID
604944Gene Ontology
HyperlinkGene Summary
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
PP2A, subunit B, B''-PR72/PR130|PP2A, subunit B, B72/B130 isoforms|PP2A, subunit B, R3 isoform|Serine/threonine protein phosphatase 2A, 72/130 kDa regulatory subunit B|protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and
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Interactome
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Disease
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Publication Reference
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Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2.
Zhang S, Cagatay T, Amanai M, Zhang M, Kline J, Castrillon DH, Ashfaq R, Oz OK, Wharton KA Jr.
Molecular and Cellular Biology 2007 Jun; 27(12):4454.
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Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2.
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