NRG3 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of NRG3.
Immunogen
A synthetic peptide corresponding to human NRG3.
Sequence
C-RNEIQRDSALTK
Host
Goat
Theoretical MW (kDa)
75
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
NRG3 polyclonal antibody (Cat # PAB7582) (0.3 ug/mL) staining of human brain (cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NRG3
Entrez GeneID
10718Protein Accession#
NP_001010848.2Gene Name
NRG3
Gene Alias
HRG3, pro-NRG3
Gene Description
neuregulin 3
Omim ID
605533Gene Ontology
HyperlinkGene Summary
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified
Other Designations
neuregulin-3-like polypeptide
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Interactome
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Pathway
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Disease
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Publication Reference
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NRG-3 in human breast cancers: activation of multiple erbB family proteins.
Hijazi MM, Young PE, Dougherty MK, Bressette DS, Cao TT, Pierce JH, Wong LM, Alimandi M, King CR.
International Journal of Oncology 1998 Nov; 13(5):1061.
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NRG-3 in human breast cancers: activation of multiple erbB family proteins.
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