MARK2 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
MARK2 polyclonal antibody (Cat # PAB7578) (0.3 ug/mL) staining of human brain (cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of MARK2.
Immunogen
A synthetic peptide corresponding to human MARK2.
Sequence
C-QNGKDSTAPQR
Host
Goat
Theoretical MW (kDa)
84.3, 77.6
Reactivity
Human
Specificity
This antibody is to recognize the reported isoforms (NP_001034557.1; NP_004945.3).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
MARK2 polyclonal antibody (Cat # PAB7578) (0.3 ug/mL) staining of human brain (cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MARK2
Entrez GeneID
2011Protein Accession#
NP_001034557.1;NP_001034558.1;NP_004945.3;NP_059672.2Gene Name
MARK2
Gene Alias
EMK1, MGC99619, PAR-1, Par1b
Gene Description
MAP/microtubule affinity-regulating kinase 2
Omim ID
600526Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
ELKL motif kinase 1|Ser/Thr protein kinase PAR-1B|protein-serine/threonine kinase|serine/threonine kinase
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Interactome
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Disease
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Publication Reference
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Prognosis in human melanoma: PAR-1 expression is superior to other coagulation components and VEGF.
Depasquale I, Thompson WD.
Histopathology 2008 Mar; 52(4):500.
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Prognosis in human melanoma: PAR-1 expression is superior to other coagulation components and VEGF.
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