IGFBP3 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of IGFBP3.
Immunogen
A synthetic peptide corresponding to human IGFBP3.
Sequence
C-RYKVDYESQSTDTQN
Host
Goat
Theoretical MW (kDa)
31.7, 32.2
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_001013416.1 and NP_000589.2).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Western Blot (0.02-0.06 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
IGFBP3 polyclonal antibody (Cat # PAB7567) (0.02 ug/mL) staining of human breast cancer lysate (35 ug protein in RIPA buffer) with (B) and without (A) blocking with the immunising peptide. Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — IGFBP3
Entrez GeneID
3486Protein Accession#
NP_001013416.1;NP_000589.2Gene Name
IGFBP3
Gene Alias
BP-53, IBP3
Gene Description
insulin-like growth factor binding protein 3
Omim ID
146732Gene Ontology
HyperlinkGene Summary
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
IGF-binding protein 3|acid stable subunit of the 140 K IGF complex|binding protein 29|binding protein 53|growth hormone-dependent binding protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Intakes of calcium and vitamin D and breast cancer risk in women.
Lin J, Manson JE, Lee IM, Cook NR, Buring JE, Zhang SM.
Archives of Internal Medicine 2007 May; 167(10):1050.
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Intakes of calcium and vitamin D and breast cancer risk in women.
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