GSTM3 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GSTM3.
Immunogen
A synthetic peptide corresponding to human GSTM3.
Sequence
RTQLIRLCYSSDHE
Host
Goat
Theoretical MW (kDa)
26.6
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:4000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — GSTM3
Entrez GeneID
2947Protein Accession#
NP_000840.2Gene Name
GSTM3
Gene Alias
GST5, GSTB, GSTM3-3, GTM3, MGC3310, MGC3704
Gene Description
glutathione S-transferase mu 3 (brain)
Omim ID
138390Gene Ontology
HyperlinkGene Summary
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
GST class-mu 3|OTTHUMP00000013355|S-(hydroxyalkyl)glutathione lyase M3|brain GST|brain type mu-glutathione S-transferase|glutathione S-alkyltransferase M3|glutathione S-aralkyltransferase M3|glutathione S-aryltransferase M3|glutathione S-transferase M3 (b
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Interactome
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Pathway
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Disease
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Publication Reference
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Gene variations in GSTM3 are a risk factor for Alzheimer's disease.
Hong GS, Heun R, Jessen F, Popp J, Hentschel F, Kelemen P, Schulz A, Maier W, Kolsch H.
Neurobiology of Aging 2009 May; 30(5):691.
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Gene variations in GSTM3 are a risk factor for Alzheimer's disease.
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