DIO2 polyclonal antibody
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More Files
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Immunohistochemistry (Frozen sections)
DIO2 polyclonal antibody (Cat # PAB7542, 2 ug/mL) staining of PFA-fixed cryo-sectioned mouse hippocampus. Microwaved antigen retrieval with citrate buffer pH 4.5, HRP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DIO2.
Immunogen
A synthetic peptide corresponding to human DIO2.
Sequence
EVKKHQNQEDRC
Host
Goat
Theoretical MW (kDa)
30.5, 34.6
Reactivity
Mouse
Specificity
This antibody is expected to recognize both reported isoform a (NP_000784.2 and NP_054644.1) and isoform b (NP_001007024.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Immunohistochemistry (Frozen sections) (2-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Frozen sections)
DIO2 polyclonal antibody (Cat # PAB7542, 2 ug/mL) staining of PFA-fixed cryo-sectioned mouse hippocampus. Microwaved antigen retrieval with citrate buffer pH 4.5, HRP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DIO2
Entrez GeneID
1734Protein Accession#
NP_000784.2;NP_054644.1;NP_001007024.1Gene Name
DIO2
Gene Alias
5DII, D2, SelY, TXDI2
Gene Description
deiodinase, iodothyronine, type II
Omim ID
601413Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
thyroxine deiodinase, type II|type 2 iodothyronine deiodinase|type-II 5'deiodinase
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Interactome
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Disease
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Publication Reference
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Ala92 type 2 deiodinase allele increases risk for the development of hypertension.
Gumieniak O, Perlstein TS, Williams JS, Hopkins PN, Brown NJ, Raby BA, Williams GH.
Hypertension 2007 Mar; 49(3):461.
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Ala92 type 2 deiodinase allele increases risk for the development of hypertension.
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