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DIO2 polyclonal antibody

  • Catalog # : PAB7542
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of DIO2.
  • Immunogen:
  • A synthetic peptide corresponding to human DIO2.
  • Sequence:
  • EVKKHQNQEDRC
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 30.5, 34.6
  • Reactivity:
  • Mouse
  • Specificity:
  • This antibody is expected to recognize both reported isoform a (NP_000784.2 and NP_054644.1) and isoform b (NP_001007024.1).
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • ELISA (1:128000)
    Immunohistochemistry (Frozen sections) (2-3 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Immunohistochemistry (Frozen sections)
  • Immunohistochemistry (Frozen sections)
  • DIO2 polyclonal antibody (Cat # PAB7542, 2 ug/mL) staining of PFA-fixed cryo-sectioned mouse hippocampus. Microwaved antigen retrieval with citrate buffer pH 4.5, HRP-staining.
  • ELISA
  • Application Image
  • Immunohistochemistry (Frozen sections)
  • Immunohistochemistry (Frozen sections)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 1734
  • Protein Accession#:
  • NP_000784.2;NP_054644.1;NP_001007024.1
  • Gene Name:
  • DIO2
  • Gene Alias:
  • 5DII,D2,SelY,TXDI2
  • Gene Description:
  • deiodinase, iodothyronine, type II
  • Gene Summary:
  • The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
  • Other Designations:
  • thyroxine deiodinase, type II,type 2 iodothyronine deiodinase,type-II 5'deiodinase
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