DACH2 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DACH2.
Immunogen
A synthetic peptide corresponding to human DACH2.
Sequence
C-TRKQAVNSSRPGR
Host
Goat
Theoretical MW (kDa)
65.3
Reactivity
Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
Western Blot (0.03-0.1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
DACH2 polyclonal antibody (Cat # PAB7541) (0.03 ug/mL) staining of NIH/3T3 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DACH2
Entrez GeneID
117154Protein Accession#
NP_444511.1Gene Name
DACH2
Gene Alias
FLJ31391, MGC138545
Gene Description
dachshund homolog 2 (Drosophila)
Omim ID
300608Gene Ontology
HyperlinkGene Summary
This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
dachshund 2
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Interactome
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Disease
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Publication Reference
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DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.
Wu K, Yang Y, Wang C, Davoli MA, D'Amico M, Li A, Cveklova K, Kozmik Z, Lisanti MP, Russell RG, Cvekl A, Pestell RG.
The Journal of Biological Chemistry 2003 Dec; 278(51):51673.
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DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.
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