CHRNA4 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CHRNA4.
Immunogen
A synthetic peptide corresponding to human CHRNA4.
Sequence
C-RASSHVETRAHAE
Host
Goat
Theoretical MW (kDa)
70
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:4000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CHRNA4
Entrez GeneID
1137Protein Accession#
NP_000735.1Gene Name
CHRNA4
Gene Alias
BFNC, EBN, EBN1, FLJ95812, NACHR, NACHRA4, NACRA4
Gene Description
cholinergic receptor, nicotinic, alpha 4
Gene Ontology
HyperlinkGene Summary
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. [provided by RefSeq
Other Designations
cholinergic receptor, nicotinic, alpha 4 subunit|cholinergic receptor, nicotinic, alpha polypeptide 4|neuronal nicotinic acetylcholine receptor alpha-4 subunit
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Interactome
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Disease
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Publication Reference
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How mutations in the nAChRs can cause ADNFLE epilepsy.
Bertrand D, Picard F, Le Hellard S, Weiland S, Favre I, Phillips H, Bertrand S, Berkovic SF, Malafosse A, Mulley J.
Epilepsia 2002 Jan; 43 Suppl 5:112.
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How mutations in the nAChRs can cause ADNFLE epilepsy.
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