CES1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
CES1 polyclonal antibody (Cat # PAB7531) (0.03 ug/mL) staining of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
CES1 polyclonal antibody (Cat # PAB7531) (2.5 ug/mL) staining of paraffin embedded human lung. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CES1.
Immunogen
A synthetic peptide corresponding to human CES1.
Sequence
C-NTQAAQKLKDKE
Host
Goat
Theoretical MW (kDa)
62.6, 62.5, 62.4
Reactivity
Human
Specificity
This antibody is expected to recognize all three reported isoforms (NP_001020366.1; NP_001020365.1; NP_001257.4).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Western blot (0.03-0.1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CES1 polyclonal antibody (Cat # PAB7531) (0.03 ug/mL) staining of human liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
CES1 polyclonal antibody (Cat # PAB7531) (2.5 ug/mL) staining of paraffin embedded human lung. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CES1
Entrez GeneID
1066Protein Accession#
NP_001020366.1;NP_001020365.1;NP_001257.4Gene Name
CES1
Gene Alias
ACAT, CEH, CES2, HMSE, HMSE1, MGC117365, PCE-1, SES1, TGH
Gene Description
carboxylesterase 1 (monocyte/macrophage serine esterase 1)
Omim ID
114835Gene Ontology
HyperlinkGene Summary
Carboxylesterase 1 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolize long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds. Carboxylesterase deficiency may be associated with non-Hodgkin lymphoma or B-cell lymphocytic leukemia. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq
Other Designations
acyl coenzyme A:cholesterol acyltransferase|carboxylesterase 1|carboxylesterase 2 (liver)|cholesteryl ester hydrolase|egasyn|liver carboxylesterase|triacylglycerol hydrolase
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Interactome
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Pathway
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Disease
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Publication Reference
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Adipocyte triglyceride lipase expression in human obesity.
Steinberg GR, Kemp BE, Watt MJ.
American Journal of Physiology. Endocrinology and Metabolism 2007 Oct; 293(4):E958.
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Adipocyte triglyceride lipase expression in human obesity.
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