CRHR1 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CRHR1.
Immunogen
A synthetic peptide corresponding to amino acids 250-263 of human CRHR1.
Sequence
KLYYDNEKCWFGKR
Host
Goat
Theoretical MW (kDa)
47.7
Reactivity
Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CRHR1
Entrez GeneID
1394Protein Accession#
NP_004373.2Gene Name
CRHR1
Gene Alias
CRF-R, CRF1, CRFR1, CRH-R1h, CRHR, CRHR1f
Gene Description
corticotropin releasing hormone receptor 1
Omim ID
122561Gene Ontology
HyperlinkGene Summary
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants
Other Designations
CRF1 receptor isoform I variant B|corticotropin releasing hormone receptor variant 1h|corticotropin-releasing factor receptor|seven transmembrane helix receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons.
Ungless MA, Singh V, Crowder TL, Yaka R, Ron D, Bonci A.
Neuron 2003 Jul; 39(3):401.
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Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons.
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