SECISBP2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
SECISBP2 polyclonal antibody (Cat # PAB7505) staining of HFF cell lysate with B) 100nM siRNA or A) control siRNA. Detected by chemiluminescence. Data kindly provided by Laura Papp and Kum Kum Khanna, Brisbane, Australia.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
SECISBP2 polyclonal antibody (Cat # PAB7505, 3 ug/mL) staining of paraffin embedded human testis. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SECISBP2.
Immunogen
A synthetic peptide corresponding to internal region of human SECISBP2.
Sequence
C-KERQERKQRLQEN
Host
Goat
Theoretical MW (kDa)
120
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:64000)
Western blot (0.1-0.3 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
SECISBP2 polyclonal antibody (Cat # PAB7505) staining of HFF cell lysate with B) 100nM siRNA or A) control siRNA. Detected by chemiluminescence. Data kindly provided by Laura Papp and Kum Kum Khanna, Brisbane, Australia.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
SECISBP2 polyclonal antibody (Cat # PAB7505, 3 ug/mL) staining of paraffin embedded human testis. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining.Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — SECISBP2
Entrez GeneID
79048Protein Accession#
NP_076982.3Gene Name
SECISBP2
Gene Alias
DKFZp686C09169, SBP2
Gene Description
SECIS binding protein 2
Gene Ontology
HyperlinkGene Summary
The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. [provided by RefSeq
Other Designations
OTTHUMP00000021618|OTTHUMP00000064929|OTTHUMP00000064930|OTTHUMP00000064931|OTTHUMP00000064932|selenocysteine insertion sequence binding protein 2
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Interactome
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Disease
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Publication Reference
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Functional characterization of alternatively spliced human SECISBP2 transcript variants.
Papp LV, Wang J, Kennedy D, Boucher D, Zhang Y, Gladyshev VN, Singh RN, Khanna KK.
Nucleic Acids Research 2008 Dec; 36(22):7192.
Application：IF, WB-Tr, Human, C33A, HEK 293T cells.
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Functional characterization of alternatively spliced human SECISBP2 transcript variants.
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