TRPC6 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TRPC6.
Immunogen
A synthetic peptide corresponding to human TRPC6.
Sequence
C-EKLSMEPNQEETN
Host
Goat
Theoretical MW (kDa)
106
Reactivity
Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
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Gene Info — TRPC6
Entrez GeneID
7225Protein Accession#
NP_004612.2Gene Name
TRPC6
Gene Alias
FLJ11098, FLJ14863, FSGS2, TRP6
Gene Description
transient receptor potential cation channel, subfamily C, member 6
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq
Other Designations
transient receptor potential channel 6
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Interactome
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Disease
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Publication Reference
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A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis.
Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, Hawkins AF, Daskalakis N, Kwan SY, Ebersviller S, Burchette JL, Pericak-Vance MA, Howell DN, Vance JM, Rosenberg PB.
Science 2005 May; 308(5729):1801.
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A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis.
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