AKAP9 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of AKAP9.
Immunogen
A synthetic peptide corresponding to human AKAP9.
Sequence
C-SGSTTQFHAGMR
Host
Goat
Theoretical MW (kDa)
453, 452
Reactivity
Human
Specificity
This antibody is expected to recognize isoforms 1, 2 and 3 (NP_671700.1, NP_005742.4, NP_671714.1 respectively). The isoforms Yotiao, AKAP350B and AKAP350C are not recognized.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — AKAP9
Entrez GeneID
10142Protein Accession#
NP_671700.1;NP_005742.4;NP_671714.1Gene Name
AKAP9
Gene Alias
AKAP350, AKAP450, CG-NAP, HYPERION, KIAA0803, MU-RMS-40.16A, PRKA9, YOTIAO
Gene Description
A kinase (PRKA) anchor protein (yotiao) 9
Omim ID
604001Gene Ontology
HyperlinkGene Summary
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq
Other Designations
A-kinase anchor protein 9|A-kinase anchor protein, 350kDa|A-kinase anchoring protein 450|AKAP120-like protein|AKAP9-BRAF fusion protein|centrosome- and golgi-localized protein|kinase N-associated protein|protein kinase A anchoring protein 9
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Interactome
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Disease
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Publication Reference
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Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer.
Ciampi R, Knauf JA, Kerler R, Gandhi M, Zhu Z, Nikiforova MN, Rabes HM, Fagin JA, Nikiforov YE.
The Journal of Clinical Investigation 2005 Jan; 115(1):94.
Application:IHC-Fr, IHC-P, WB, Human, Brains, Thyroid cancer.
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Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer.
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