ABCC5 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Tissue lysate)
ABCC5 polyclonal antibody (Cat # PAB7484) (0.5 ug/mL) staining of human frontal cortex lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
-
Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ABCC5.
Immunogen
A synthetic peptide corresponding to human ABCC5.
Sequence
KDIDIGKEYIIP-C
Host
Goat
Theoretical MW (kDa)
161, 23.7
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_005679.2, NP_001018881.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
ABCC5 polyclonal antibody (Cat # PAB7484) (0.5 ug/mL) staining of human frontal cortex lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
-
Gene Info — ABCC5
Entrez GeneID
10057Protein Accession#
NP_005679.2;NP_001018881.1Gene Name
ABCC5
Gene Alias
ABC33, DKFZp686C1782, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11
Gene Description
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
Omim ID
605251Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq
Other Designations
ATP-binding cassette, sub-family C, member 5|canalicular multispecific organic anion transporter C
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Effects of Chronic Renal Failure on Brain Drug Transporters in Rats.
Naud J, Laurin LP, Michaud J, Beauchemin S, Leblond FA, Pichette V.
Drug Metabolism and Disposition: the Biological Fate of Chemicals 2012 Jan; 40(1):39.
Application：WB, Rat, Rat brains.
-
Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation.
Meyer Zu Schwabedissen HE, Grube M, Heydrich B, Linnemann K, Fusch C, Kroemer HK, Jedlitschky G.
The American Journal of Pathology 2005 Jan; 166(1):39.
Application：IF, IHC, WB-Ti, Human, Placenta, Cytotrophoblasts.
-
Effects of Chronic Renal Failure on Brain Drug Transporters in Rats.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com