HCRTR1/HCRTR2 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of HCRTR1/HCRTR2.
Immunogen
A synthetic peptide corresponding to human HCRTR1/HCRTR2.
Sequence
C-YNFLSGKFREQFK
Host
Goat
Theoretical MW (kDa)
47.5
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The HCRTR1/HCRTR2 polyclonal antibody (Cat # PAB7477) (0.5 ug/mL) staining of human frontal cortex lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — HCRTR1
Entrez GeneID
3061Protein Accession#
NP_001516 (Gene ID : 3061);NP_001517.1 (Gene ID : 3062)Gene Name
HCRTR1
Gene Alias
OX1R
Gene Description
hypocretin (orexin) receptor 1
Omim ID
602392Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq
Other Designations
OTTHUMP00000003951|hypocretin receptor 1|hypocretin receptor-1|orexin receptor 1|orexin receptor-1
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Gene Info — HCRTR2
Entrez GeneID
3062Protein Accession#
NP_001516 (Gene ID : 3061);NP_001517.1 (Gene ID : 3062)Gene Name
HCRTR2
Gene Alias
OX2R
Gene Description
hypocretin (orexin) receptor 2
Omim ID
602393Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq
Other Designations
OTTHUMP00000017762|OTTHUMP00000039969|hypocretin receptor-2|orexin receptor 2
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Interactome
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Pathway
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Disease
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Publication Reference
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The orexin 1 receptor (HCRTR1) gene as a susceptibility gene contributing to polydipsia-hyponatremia in schizophrenia.
Fukunaka Y, Shinkai T, Hwang R, Hori H, Utsunomiya K, Sakata S, Naoe Y, Shimizu K, Matsumoto C, Ohmori O, Nakamura J.
Neuromolecular Medicine 2007 Aug; 9(4):292.
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The orexin 1 receptor (HCRTR1) gene as a susceptibility gene contributing to polydipsia-hyponatremia in schizophrenia.
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