CTSK polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
CTSK polyclonal antibody (Cat # PAB7476) (1 ug/mL) staining of human lung lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CTSK.
Immunogen
A synthetic peptide corresponding to human CTSK.
Sequence
C-KTHRKQYNNKVDE
Host
Goat
Theoretical MW (kDa)
37
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CTSK polyclonal antibody (Cat # PAB7476) (1 ug/mL) staining of human lung lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CTSK
Entrez GeneID
1513Protein Accession#
NP_000387.1Gene Name
CTSK
Gene Alias
CTS02, CTSO, CTSO1, CTSO2, MGC23107, PKND, PYCD
Gene Description
cathepsin K
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq
Other Designations
OTTHUMP00000032938|cathepsin O1|cathepsin O2|cathepsin X
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Interactome
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Pathway
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Disease
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Publication Reference
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Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H.
Science 2008 Feb; 319(5863):624.
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Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
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