RNF34 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of RNF34.
Immunogen
A synthetic peptide corresponding to human RNF34.
Sequence
C-RLYKENEENQKSY
Host
Goat
Theoretical MW (kDa)
41.7, 41.6
Specificity
This antibody is expected to recognize both reported isoforms (NP_919247.1; NP_079402.2).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:64000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — RNF34
Entrez GeneID
80196Protein Accession#
NP_919247.1;NP_079402.2Gene Name
RNF34
Gene Alias
FLJ21786, RFI, RIF, RIFF
Gene Description
ring finger protein 34
Omim ID
608299Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
FYVE-RING finger protein MOMO|RING finger protein RIFF
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Interactome
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Publication Reference
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Overexpression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells.
Konishi T, Sasaki S, Watanabe T, Kitayama J, Nagawa H.
Molecular Cancer Therapeutics 2005 May; 4(5):743.
Application：WB, Human, Colo201, DLD-1, HCT-116, HT-29, LoVo, SW948, WiDr cells.
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Overexpression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells.
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