AICDA polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of AICDA.
Immunogen
A synthetic peptide corresponding to human AICDA.
Sequence
RRKFLYQFKNVR-C
Host
Goat
Theoretical MW (kDa)
24
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:1000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
AICDA polyclonal antibody (Cat # PAB7460) (0.1 ug/mL) staining of human tonsil lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — AICDA
Entrez GeneID
57379Protein Accession#
NP_065712.1Gene Name
AICDA
Gene Alias
AID, ARP2, CDA2, HIGM2
Gene Description
activation-induced cytidine deaminase
Gene Ontology
HyperlinkGene Summary
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq
Other Designations
activation-induced deaminase|integrated into Burkitt's lymphoma cell line Ramos
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Interactome
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Pathway
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Disease
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Publication Reference
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Regulation of AID expression in the immune response.
Crouch EE, Li Z, Takizawa M, Fichtner-Feigl S, Gourzi P, Montano C, Feigenbaum L, Wilson P, Janz S, Papavasiliou FN, Casellas R.
The Journal of Experimental Medicine 2007 May; 204(5):1145.
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Regulation of AID expression in the immune response.
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