MC2R polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of MC2R.
Immunogen
A synthetic peptide corresponding to human MC2R.
Sequence
ENINNTARNNSDC
Host
Goat
Theoretical MW (kDa)
33.9
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
MC2R polyclonal antibody (Cat # PAB7439) (1 ug/mL) staining of human skin lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MC2R
Entrez GeneID
4158Protein Accession#
NP_000520.1Gene Name
MC2R
Gene Alias
ACTHR, MGC125798
Gene Description
melanocortin 2 receptor (adrenocorticotropic hormone)
Gene Ontology
HyperlinkGene Summary
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. [provided by RefSeq
Other Designations
ACTH receptor|MC2 receptor|OTTHUMP00000162512|adrenocorticotropic hormone receptor|corticotropin receptor|melanocortin 2 receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization.
Kilianova Z, Basora N, Kilian P, Payet MD, Gallo-Payet N.
Endocrinology 2006 May; 147(5):2325.
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Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization.
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