CCBL1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CCBL1.
Immunogen
A synthetic peptide corresponding to human CCBL1.
Sequence
C-DISDFKRKMPD
Host
Goat
Theoretical MW (kDa)
47.9, 42.6
Specificity
This antibody is expected to recognize both reported isoforms (NP_004050.3, NP_001116144.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CCBL1
Entrez GeneID
883Protein Accession#
NP_004050.3;NP_001116144.1Gene Name
CCBL1
Gene Alias
FLJ95217, GTK, KAT1, KATI, MGC29624
Gene Description
cysteine conjugate-beta lyase, cytoplasmic
Omim ID
600547Gene Ontology
HyperlinkGene Summary
This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000022311|beta-lysase, kidney|cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)|cytoplasmic cysteine conjugate-beta lyase|glutamine transaminase K|glutamine-phenylpyruvate aminotransferase|kyneure
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Interactome
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Publication Reference
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The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants.
Cooper AJ.
Neurochemistry International 2004 Jun; 44(8):557.
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The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants.
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