MAN2A1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of MAN2A1.
Immunogen
A synthetic peptide corresponding to internal region of human MAN2A1.
Sequence
C-KISSDIKSQNR
Host
Goat
Theoretical MW (kDa)
131
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
MAN2A1 polyclonal antibody (Cat # PAB7421) (0.3 ug/mL) staining of human placenta lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Western Blot (Transfected lysate)
293 overexpressing MAN2A1 and probed with MAN2A1 polyclonal antibody (Cat # PAB7421) (mock transfection in first lane), tested by Origene.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MAN2A1
Entrez GeneID
4124Protein Accession#
NP_002363.2Gene Name
MAN2A1
Gene Alias
GOLIM7, MANA2, MANII
Gene Description
mannosidase, alpha, class 2A, member 1
Omim ID
154582Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq
Other Designations
Golgi alpha-mannosidase II|golgi integral membrane protein 7|mannosidase, alpha type II|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
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Interactome
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Pathway
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Disease
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Publication Reference
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Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis.
Green RS, Stone EL, Tenno M, Lehtonen E, Farquhar MG, Marth JD.
Immunity 2007 Aug; 27(2):308.
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Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis.
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