NLGN3 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
NLGN3 polyclonal antibody (Cat # PAB7418) (0.1 ug/mL) staining of human brain (amygdala) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Western Blot (Transfected lysate)
293 overexpressing NLGN3 and probed with NLGN3 polyclonal antibody (Cat # PAB7418) (mock transfection in first lane), tested by Origene.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of NLGN3.
Immunogen
A synthetic peptide corresponding to human NLGN3.
Sequence
C-RKDKRRQEPLRQPS
Host
Goat
Theoretical MW (kDa)
91.5
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (0.05-0.2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
NLGN3 polyclonal antibody (Cat # PAB7418) (0.1 ug/mL) staining of human brain (amygdala) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Western Blot (Transfected lysate)
293 overexpressing NLGN3 and probed with NLGN3 polyclonal antibody (Cat # PAB7418) (mock transfection in first lane), tested by Origene.Enzyme-linked Immunoabsorbent Assay
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Gene Info — NLGN3
Entrez GeneID
54413Protein Accession#
NP_061850.2Gene Name
NLGN3
Gene Alias
ASPGX1, AUTSX1, HNL3, KIAA1480
Gene Description
neuroligin 3
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000023498
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Interactome
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Pathway
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Disease
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Publication Reference
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A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Sudhof TC.
Science 2007 Oct; 318(5847):71.
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A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
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