EPHB4 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of EPHB4.
Immunogen
A synthetic peptide corresponding to amino acids 566-578 of human EPHB4.
Sequence
C-QSNGREAEYSDKH
Host
Goat
Theoretical MW (kDa)
108
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — EPHB4
Entrez GeneID
2050Protein Accession#
NP_004435.3Gene Name
EPHB4
Gene Alias
HTK, MYK1, TYRO11
Gene Description
EPH receptor B4
Omim ID
600011Gene Ontology
HyperlinkGene Summary
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq
Other Designations
ephrin receptor EphB4|hepatoma transmembrane kinase|soluble EPHB4 variant 1|soluble EPHB4 variant 2|soluble EPHB4 variant 3
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Interactome
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Pathway
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Disease
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Publication Reference
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The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome.
Kumar SR, Masood R, Spannuth WA, Singh J, Scehnet J, Kleiber G, Jennings N, Deavers M, Krasnoperov V, Dubeau L, Weaver FA, Sood AK, Gill PS.
British Journal of Cancer 2007 Apr; 96(7):1083.
Application：IHC-P, WB, Human, CAOV-3, Hey, HOC-7, MCV-50, ML-5, OVCAR-3 cells, Human ovarian carcinoma.
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The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome.
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