HCRTR2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of HCRTR2.
Immunogen
A synthetic peptide corresponding to human HCRTR2.
Sequence
SGTKLEDSPPCRN
Host
Goat
Theoretical MW (kDa)
50.7
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
HCRTR2 polyclonal antibody (Cat # PAB7387) (1 ug/mL) staining of human brain (hippocampus) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — HCRTR2
Entrez GeneID
3062Protein Accession#
NP_001517.1Gene Name
HCRTR2
Gene Alias
OX2R
Gene Description
hypocretin (orexin) receptor 2
Omim ID
602393Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq
Other Designations
OTTHUMP00000017762|OTTHUMP00000039969|hypocretin receptor-2|orexin receptor 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells.
Spinazzi R, Rucinski M, Neri G, Malendowicz LK, Nussdorfer GG.
The Journal of Clinical Endocrinology and Metabolism 2005 Jun; 90(6):3544.
Application:WB-Ti, Human, adrenal cortex.
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Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells.
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