SETD2 polyclonal antibody (Cat # PAB7385) (0.5 ug/mL) staining of mouse fibroblast lysates transiently expressing different siRNA in second and third lane (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq
SET domain-containing protein 2,histone-lysine N-methyltransferase SETD2,huntingtin interacting protein 1,huntingtin yeast partner B,huntingtin-interacting protein B,lysine N-methyltransferase 3A