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Last updated: 2017/10/15
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SETD2 polyclonal antibody

  • Catalog # : PAB7385
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of SETD2.
  • Immunogen:
  • A synthetic peptide corresponding to internal region of human SETD2.
  • Sequence:
  • C-ERDPDKQTQNKE
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 231
  • Reactivity:
  • Mouse
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Recommend Usage:
  • ELISA (1:4000)
    Western Blot (0.5-2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • 1.
  • SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis.
    Martinelli G, Mancini M, De Benedittis C, Rondoni M, Papayannidis C, Manfrini M, Meggendorfer M, Calogero R, Guadagnuolo V, Fontana MC, Bavaro L, Padella A, Zago E, Pagano L, Zanotti R, Scaffidi L, Specchia G, Albano F, Merante S, Elena C, Savini P, Gangemi D, Tosi P, Ciceri F, Poletti G, Riccioni L, Morigi F, Delledonne M, Haferlach T, Cavo M, Valent P, Soverini S.Leukemia. 2017 Jun 16. [Epub ahead of print]
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • SETD2 polyclonal antibody (Cat # PAB7385) (0.5 ug/mL) staining of mouse fibroblast lysates transiently expressing different siRNA in second and third lane (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Gene Name:
  • SETD2
  • Gene Alias:
  • FLJ16420,FLJ22472,FLJ23184,FLJ45883,FLJ46217,HIF-1,HSPC069,HYPB,KIAA1732,KMT3A,SET2,p231HBP
  • Gene Description:
  • SET domain containing 2
  • Gene Summary:
  • Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq
  • Other Designations:
  • SET domain-containing protein 2,histone-lysine N-methyltransferase SETD2,huntingtin interacting protein 1,huntingtin yeast partner B,huntingtin-interacting protein B,lysine N-methyltransferase 3A
  • Gene Pathway
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