MAP3K7IP3 polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of MAP3K7IP3.
Immunogen
A synthetic peptide corresponding to amino acids 274-285 of human MAP3K7IP3.
Sequence
C-NYQPSQYSPKQQ
Host
Goat
Theoretical MW (kDa)
78.7
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — MAP3K7IP3
Entrez GeneID
257397Protein Accession#
NP_690000.2Gene Name
MAP3K7IP3
Gene Alias
MGC45404, NAP1, TAB3
Gene Description
mitogen-activated protein kinase kinase kinase 7 interacting protein 3
Omim ID
300480Gene Ontology
HyperlinkGene Summary
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq
Other Designations
Mitogen-activated protein kinase kinase kinase 7-interacting protein 3|NF-kappa-B-activating protein 1|NFkB activating protein 1|OTTHUMP00000023112|TAK1 binding protein 3|TAK1-binding protein 3
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Interactome
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Publication Reference
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XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization.
Lu M, Lin SC, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H.
Molecular Cell 2007 Jun; 26(5):689.
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XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization.
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