FSCN2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of FSCN2.
Immunogen
A synthetic peptide corresponding to internal region of human FSCN2.
Sequence
CHHRGSNQLDTNR
Host
Goat
Theoretical MW (kDa)
57.4, 55.1
Reactivity
Mouse
Specificity
This antibody is expected to recognize both reported isoforms (NP_001070650.1 and NP_0.36550.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:64000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — FSCN2
Entrez GeneID
25794Protein Accession#
NP_001070650.1;NP_0.36550.1Gene Name
FSCN2
Gene Alias
RFSN, RP30
Gene Description
fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the fascin protein family. Fascins crosslink actin into filamentous bundles within dynamic cell extensions. This family member is proposed to play a role in photoreceptor disk morphogenesis. A mutation in this gene results in one form of autosomal dominant retinitis pigmentosa and macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
fascin 2|retinal fascin
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Interactome
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Disease
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Publication Reference
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The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice.
Jung-Bum Shin, Chantal M Longo-Guess, Leona H Gagnon, Katherine W Saylor, Rachel A Dumont, Kateri J Spinelli, James M Pagana, Phillip A Wilmarth, Larry L David, Peter G Gillespie, Kenneth R Johnson.
Journal of Neuroscience 2010 Jul; 30(29):9683.
Application:IF, Chicken, Chicken utricles.
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Role of fascin in filopodial protrusion.
Vignjevic D, Kojima S, Aratyn Y, Danciu O, Svitkina T, Borisy GG.
The Journal of Cell Biology 2006 Sep; 174(6):863.
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The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice.
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