GRIK1 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
GRIK1 polyclonal antibody (Cat # PAB7354) (1 ug/mL) staining of human brain (cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GRIK1.
Immunogen
A synthetic peptide corresponding to human GRIK1.
Sequence
QCKQTHPTNSTS
Host
Goat
Theoretical MW (kDa)
104, 103
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms according to NP_000821.1 and NP_783300.1.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:8000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
GRIK1 polyclonal antibody (Cat # PAB7354) (1 ug/mL) staining of human brain (cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GRIK1
Entrez GeneID
2897Protein Accession#
NP_000821.1;NP_783300.1Gene Name
GRIK1
Gene Alias
EAA3, EEA3, GLR5, GLUR5
Gene Description
glutamate receptor, ionotropic, kainate 1
Omim ID
138245Gene Ontology
HyperlinkGene Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000096569|excitatory amino acid receptor 3|glutamate receptor 5
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Interactome
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Pathway
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Disease
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Publication Reference
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SUMOylation regulates kainate-receptor-mediated synaptic transmission.
Martin S, Nishimune A, Mellor JR, Henley JM.
Nature 2007 May; 447(7142):321.
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SUMOylation regulates kainate-receptor-mediated synaptic transmission.
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