THRA polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
THRA polyclonal antibody (Cat # PAB7338) (0.5 ug/mL) staining of human bone marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of THRA.
Immunogen
A synthetic peptide corresponding to human THRA.
Sequence
C-KEEMIRSLQQRP
Host
Goat
Theoretical MW (kDa)
46.8, 54.8
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_955366.1; NP_003241.2). This antibody is not expected to cross-react to THRB.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.5-1.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
THRA polyclonal antibody (Cat # PAB7338) (0.5 ug/mL) staining of human bone marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — THRA
Entrez GeneID
7067Protein Accession#
NP_955366.1;NP_003241.2Gene Name
THRA
Gene Alias
AR7, EAR7, ERB-T-1, ERBA, ERBA1, MGC000261, MGC43240, NR1A1, THRA1, THRA2, c-ERBA-1
Gene Description
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
Omim ID
190120Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
ERBA-related 7|OTTHUMP00000164470|avian erythroblastic leukemia viral (v-erb-a) oncogene homolog|thyroid hormone receptor alpha|thyroid hormone receptor, alpha|triiodothyronine receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Embryonic lethal effect of expressing a dominant negative mutant human thyroid hormone receptor alpha1 in mice.
Nishiyama K, Baba S, Yamada T, Matsushita A, Natsume H, Nakano K, Sasaki S, Nakamura H.
Endocrine Journal 2003 Oct; 50(5):561.
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Embryonic lethal effect of expressing a dominant negative mutant human thyroid hormone receptor alpha1 in mice.
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