MPZ polyclonal antibody
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More Files
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of MPZ.
Immunogen
A synthetic peptide corresponding to human MPZ.
Sequence
C-DHSRSTKAVSEK
Host
Goat
Theoretical MW (kDa)
28.5
Reactivity
Rat
Specificity
The presence of this PNS protein in Rat Spinal Cord is likely due to contamination with spinal roots during extraction from the animal.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
MPZ polyclonal antibody (Cat # PAB7332) (0.1 ug/mL) staining of rat spinal cord lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MPZ
Entrez GeneID
4359Protein Accession#
NP_000521.1Gene Name
MPZ
Gene Alias
CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, DSS, HMSNIB, MPP, P0
Gene Description
myelin protein zero
Gene Ontology
HyperlinkGene Summary
This gene encodes a major structural protein of peripheral myelin. Mutations in this gene result in the autosomal dominant form of Charcot-Marie-Tooth disease type 1 as other polyneuropathies. [provided by RefSeq
Other Designations
Charcot-Marie-Tooth neuropathy 1B|OTTHUMP00000032235
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Interactome
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Pathway
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Disease
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Publication Reference
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Upregulation of large myelin protein zero leads to Charcot-Marie-Tooth disease-like neuropathy in mice.
Yoshinori Otani, Nobuhiko Ohno, Jingjing Cui, Yoshihide Yamaguchi, Hiroko Baba.
Communications Biology 2020 Mar; 3(1):121.
Application:WB-Ti, Mouse, Mouse sciatic nerve homogenates.
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DHTKD1 deficiency causes Charcot-Marie-Tooth disease in mice.
Xu WY, Zhu H, Shen Y, Wan YH, Tu XD, Wu WT, Tang L, Zhang HX, Lu SY, Jin XL, Fei J, Wang ZG.
Molecular and Cellular Biology 2018 Jun; 38(13):e00085.
Application:WB-Ce, Mouse, Schwann cells.
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Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelination.
Miyamoto Y, Torii T, Takada S, Ohno N, Saitoh Y, Nakamura K, Ito A, Ogata T, Terada N, Tanoue A, Yamauchi J.
Molecular Biology of the Cell 2015 Oct; 26(19):3489.
Application:WB, Rat, Schwann cells.
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In Vivo Expression of the Arf6 Guanine-Nucleotide Exchange Factor Cytohesin-1 in Mice Exhibits Enhanced Myelin Thickness in Nerves.
Torii T, Miyamoto Y, Onami N, Tsumura H, Nemoto N, Kawahara K, Kato M, Kotera J, Nakamura K, Tanoue A, Yamauchi J.
Journal of Molecular Neuroscience 2013 Oct; 51(2):522.
Application:WB-Ti, Mouse, Sciatic nerves.
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Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development.
Yamauchi J, Miyamoto Y, Torii T, Takashima S, Kondo K, Kawahara K, Nemoto N, Chan JR, Tsujimoto G, Tanoue A.
Science Signaling 2012 Sep; 5(243):ra69.
Application:WB, Mouse, Mouse sciatic nerves.
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L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough.
Yamaguchi Y, Hayashi A, Campagnoni CW, Kimura A, Inuzuka T, Baba H.
The Journal of Biological Chemistry 2012 May; 287(21):17765.
Application:IF, WB, Rat, Rat ScN whole homogenates.
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The Atypical Guanine-Nucleotide Exchange Factor, Dock7, Negatively Regulates Schwann Cell Differentiation and Myelination.
Yamauchi J, Miyamoto Y, Hamasaki H, Sanbe A, Kusakawa S, Nakamura A, Tsumura H, Maeda M, Nemoto N, Kawahara K, Torii T, Tanoue A.
Journal of Neuroscience 2011 Aug; 31(35):12579.
Application:WB-Ti, WB-Tr, Rat, Rat sciatic nerves.
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Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10.
LeBlanc SE, Ward RM, Svaren J.
Molecular and Cellular Biology 2007 May; 27(9):3521.
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Upregulation of large myelin protein zero leads to Charcot-Marie-Tooth disease-like neuropathy in mice.
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