TREM2 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
TREM2 polyclonal antibody (Cat # PAB7324) (2.5 ug/mL) staining of paraffin embedded human spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TREM2.
Immunogen
A synthetic peptide corresponding to human TREM2.
Sequence
C-HGQKPGTHPPSELD
Host
Goat
Theoretical MW (kDa)
25.4
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Immunohistochemistry (2-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
TREM2 polyclonal antibody (Cat # PAB7324) (2.5 ug/mL) staining of paraffin embedded human spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TREM2
Entrez GeneID
54209Protein Accession#
NP_061838.1Gene Name
TREM2
Gene Alias
TREM-2, Trem2a, Trem2b, Trem2c
Gene Description
triggering receptor expressed on myeloid cells 2
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). [provided by RefSeq
Other Designations
OTTHUMP00000016368|OTTHUMP00000039771|triggering receptor expressed on monocytes 2|triggering receptor expressed on myeloid cells 2a
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Interactome
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Disease
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Publication Reference
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TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis.
Takahashi K, Prinz M, Stagi M, Chechneva O, Neumann H.
PLoS Medicine 2007 Apr; 4(4):e124.
Application：Flow Cyt, Mouse, Mouse cortex.
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TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis.
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