PHLPP2 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PHLPP2.
Immunogen
A synthetic peptide corresponding to human PHLPP2.
Sequence
C-PHEEDRTEPPEEFD
Host
Goat
Theoretical MW (kDa)
134
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
PHLPP2 polyclonal antibody (Cat # PAB7321) (0.1 ug/mL) staining of human brain (amygdala, hippocampus, substantia nigra) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PHLPP2
Entrez GeneID
23035Protein Accession#
NP_055835.2Gene Name
PHLPP2
Gene Alias
KIAA0931, PHLPP2
Gene Description
PH domain leucine-rich repeat-containing protein phosphatase 2
Omim ID
611066Gene Ontology
HyperlinkOther Designations
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Interactome
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Disease
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Publication Reference
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TBX1 functions as a tumor suppressor in thyroid cancer through inhibiting the activities of PI3K/AKT and MAPK/ERK pathways.
Na W, Li Y, Wei J, Pu J, Liu R, Yang Q, Guan H, Shi B, Hou P, Ji M.
Thyroid : Official Journal of the American Thyroid Association 2019 Mar; 29(3):378.
Application:WB, Human, BCPAP, FTC133, IHH4, K1, 8305C cells.
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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Gao T, Furnari F, Newton AC.
Molecular Cell 2005 Apr; 18(1):13.
Application:WB-Tr, Human, DLD-1, H157, HT-29, HEK 293T, LN319, LN444, MDA-MB-231 cells.
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TBX1 functions as a tumor suppressor in thyroid cancer through inhibiting the activities of PI3K/AKT and MAPK/ERK pathways.
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