IDE polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of IDE.
Immunogen
A synthetic peptide corresponding to human IDE.
Sequence
C-QQYNFDRDNTE
Host
Goat
Theoretical MW (kDa)
118, 54
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
IDE polyclonal antibody (Cat # PAB7317) (0.1 ug/mL) staining of K-562 cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Western Blot (Transfected lysate)
293 overexpressing IDE and probed with IDE polyclonal antibody (Cat # PAB7317) (mock transfection in first lane), tested by Origene.Enzyme-linked Immunoabsorbent Assay
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Gene Info — IDE
Entrez GeneID
3416Protein Accession#
NP_004960.1Gene Name
IDE
Gene Alias
FLJ35968, INSULYSIN
Gene Description
insulin-degrading enzyme
Omim ID
146680Gene Ontology
HyperlinkGene Summary
This gene may belong to a protease family responsible for intercellular peptide signalling. Though its role in the cellular processing of insulin has not yet been defined, insulin-degrading enzyme is thought to be involved in the termination of the insulin response. [provided by RefSeq
Other Designations
OTTHUMP00000020097|insulinase|insulysin
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Interactome
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Disease
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Publication Reference
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Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease.
Zhao Z, Xiang Z, Haroutunian V, Buxbaum JD, Stetka B, Pasinetti GM.
Neurobiology of Aging 2007 Jun; 28(6):824.
Application:WB-Ti, Human, Hippocampal formation, Occipital cortex.
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Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease.
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